2. Signaling Pathways
  3. Immunology/Inflammation
  4. Interleukin Related

Interleukin Related

IL

Interleukin Related

Related Products

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Interleukins are a group of cytokines (secreted proteins and signaling molecules) that were first seen to be expressed by white blood cells (leukocytes). The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4 T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T and B lymphocytes, and hematopoietic cells. Interleukin receptors on astrocytes in the hippocampus are also known to be involved in the development of spatial memories in mice.

Interleukin Related Isoform Specific Products:

Interleukin Related Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P991218
    Anti-IL11 Antibody (X203)
    		Inhibitor
    Anti-IL11 Antibody (X203) is a human-derived IgG1, κ type antibody inhibitor, targeting to human IL-11. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-IL11 Antibody (X203)
  • HY-P991288
    OPR-003
    		Inhibitor
    OPR-003 is a human monoclonal antibody targeting IL-6. OPR-003 can be used in the research of Haematological malignancies and Rheumatoid arthritis.
    OPR-003
  • HY-156340
    Anti-inflammatory agent 58
    		Inhibitor
    Anti-inflammatory agent 58 is an anti-inflammatory agent. Anti-inflammatory agent 58 inhibits IL-1β with an IC50 of 1.08 μM. Anti-inflammatory agent 58 decreases pro-inflammatory gene expression, protein secretion, and NF-κB phosphorylation.
    Anti-inflammatory agent 58
  • HY-N0633R
    Muscone (Standard)
    		Inhibitor
    Muscone (Standard) is the analytical standard of Muscone. This product is intended for research and analytical applications. Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate.
    Muscone (Standard)
  • HY-RS06765
    IL4 Human Pre-designed siRNA Set A
    		Inhibitor

    IL4 Human Pre-designed siRNA Set A contains three designed siRNAs for IL4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    IL4 Human Pre-designed siRNA Set A
    IL4 Human Pre-designed siRNA Set A
  • HY-156342
    Anti-inflammatory agent 59
    		Inhibitor
    Anti-inflammatory agent 59 is an anti-inflammatory agent. Anti-inflammatory agent 58 inhibits IL-1β with an IC50 of 2.28 μM. Anti-inflammatory agent 58 decreases pro-inflammatory gene expression, protein secretion, and NF-κB phosphorylation.
    Anti-inflammatory agent 59
  • HY-113224R
    Desmosterol (Standard)
    		Inhibitor
    Desmosterol (Standard) is the analytical standard of Desmosterol. This product is intended for research and analytical applications. Desmosterol is a cholesterol-like molecule. In the Bloch pathway of cholesterol biosynthesis, Desmosterol is a direct precursor of cholesterol. As an endogenous metabolite, Desmosterol is used to study cholesterol metabolism [1]. Desmosterol is an LXR activator and SREBP inhibitor, which can suppress macrophage inflammasome activation and prevent vascular inflammation and atherosclerosis. A reduction in Desmosterol promotes the production of mitochondrial reactive oxygen species (ROS) in macrophages and pyrin domain-dependent inflammasome activation of NLRP3. Desmosterol holds potential for research in inflammation, metabolism, and cardiovascular diseases [1][2][3].
    Desmosterol (Standard)
  • HY-W014605R
    Diphenylcyclopropenone (Standard)
    		Modulator
    Diphenylcyclopropenone (Standard) is the analytical standard of Diphenylcyclopropenone. This product is intended for research and analytical applications. Diphenylcyclopropenone (Diphencyprone) is a topical immunomodulatory agent that can be used for alopecia areata research.
    Diphenylcyclopropenone (Standard)
  • HY-P10353
    d-(RYTVELA)
    d-(RYTVELA) is a specific inhibitor of human thymocyte proliferation with an IC50 of 1 nM. d-(RYTVELA) inhibits IL-1–induced signaling pathways.
    d-(RYTVELA)
  • HY-169859
    EP4 receptor antagonist 7
    		Antagonist
    EP4 receptor antagonist 7 (Compound 14) is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 with an IC50 value of 1.1 nM. EP4 receptor antagonist 7 inhibits PGE2-induced β-arrestin recruitment in HEK293 cells with an IC50 value of 0.9 nM. EP4 receptor antagonist 7 decreases PGE2-induced expression of mRNA encoding IL-4, macrophage mannose receptor 1 (Mrc1), chitinase-like protein 3 (Chil3), chemokine (C-X-C) motif ligand 1 (Cxcl1), triggering receptor expressed on myeloid cells 2 (Trem2), and arginase-1 (Arg1), in RAW 264.7 macrophages. EP4 receptor antagonist 7 combined with an anti-PD-1 antibody inhibits tumor growth and increases infiltration of CD8+ T cells into tumors in a CT26 murine colon cancer model.
    EP4 receptor antagonist 7
  • HY-159892
    PD-1/PD-L1-IN-54
    		Activator
    PD-1/PD-L1-IN-54 (Compound 6) is a moderately affinic PD-1/PD-L1 inhibitor (KD: PD-1, 55.8 μM; PD-L1, 46.4 μM; IC50: 88.6 μM). PD-1/PD-L1-IN-54 inhibits PD-1/PD-L1 interactions and shows anticancer activity by activating CD8+ T cells, upregulating PD-1 expression, and increasing secretion of IFN-γ and IL-2. PD-1/PD-L1-IN-54 inhibits cancer cell proliferation and promotes apoptosis. PD-1/PD-L1-IN-54 also regulates T cell immunity through the PI3K/Akt pathway correlated with PD-1/PD-L1.
    PD-1/PD-L1-IN-54
  • HY-RS06672
    Il10 Rat Pre-designed siRNA Set A
    		Inhibitor

    Il10 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il10 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Il10 Rat Pre-designed siRNA Set A
    Il10 Rat Pre-designed siRNA Set A
  • HY-RS06739
    IL23A Human Pre-designed siRNA Set A
    		Inhibitor

    IL23A Human Pre-designed siRNA Set A contains three designed siRNAs for IL23A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    IL23A Human Pre-designed siRNA Set A
    IL23A Human Pre-designed siRNA Set A
  • HY-P10723
    IL-23R inhibitor peptide-1
    		Inhibitor
    IL-23R inhibitor peptide-1 (comp 475) is an interleukin-23 receptor inhibitor, with an IC50 of 0.0069 μM.
    IL-23R inhibitor peptide-1
  • HY-P991270
    MT204
    		Inhibitor
    MT204 is a humanized IgG1 antibody inhibitor targeting IL-2 of human and rhesus monkey origin. MT204 prevents soluble IL-2 from binding to intermediate-affinity IL-2 receptors and blocks CD25-bound IL-2 on high-affinity IL-2 receptors. MT204 has potently anti-proliferative activity with NKL cells and primary NK cells. MT204 has good tolerability and potent immunosuppressive activity in allogeneic skin graft model of rhesus monkey, promising for immunosuppressive and anti-proliferative therapy.
    MT204
  • HY-117843
    Ppc-1
    		Inhibitor
    Ppc-1 is a mitochondrial uncoupler. Ppc-1 enhances mitochondrial oxygen consumption without adverse effects on ATP production. Ppc-1 is a cell-permeate interleukin-2 (IL-2) inhibitor. Ppc-1 inhibits the Gram-negative periodontopathogen Porphyromonas gingivalis. Ppc-1 has anti-obesity, antibacterial and anti-inflammatory activities.
    Ppc-1
  • HY-168212
    PDE4-IN-22
    		Inhibitor
    PDE4-IN-22 (Compound 2e) is a PDE4 inhibitor with an IC50 value of 2.4 nM. PDE4-IN-22 exhibits anti-inflammatory activity and demonstrates significant anti-psoriatic effects in an Imiquimod (HY-B0180)-induced psoriasis mouse model.
    PDE4-IN-22
  • HY-N0212R
    Peimine (Standard)
    		Inhibitor
    Peimine (Standard) is the analytical standard of Peimine. This product is intended for research and analytical applications. Peimine (Verticine; Dihydroisoimperialine) is an orally active natural product. Peimine has anti-inflammatory, analgesic and cough relieving effects. Peimine can be used in cancer and inflammation related research.
    Peimine (Standard)
  • HY-173410
    iNOs-IN-6
    		Inhibitor
    iNOs-IN-6 is an anti-inflammatory agent. iNOs-IN-6 inhibits NF-κB, iNOS, and MAPK expression(IC50: 0.2-0.62 μM). iNOs-IN-6 reduces IL-6, TNF-α, and IL-1β pro-inflammatory mediators levels (IC50: 0.4-0.69 μM).
    iNOs-IN-6
  • HY-N3380
    Linderaspirone A
    		Inhibitor
    Linderaspirone A is a natural compound that can be isolated from the roots of Lindera aggregate. Linderaspirone A shows significant inhibitory effects on the production of prostaglandin E2 (PGE2),TNF-α, and IL-6 .
    Linderaspirone A
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
Interleukin Related Isoform Comparison

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